surpass-2 tirzepatide vs semaglutide nejm SURPASS-2 (NEJM 2021) was the definitive head-to-head: tirzepatide vs semaglutide 1.0 mg (the maximum approved T2DM dose) in 1,879 patients with type 2 diabetes. All three tirzepatide doses produced superior HbA1c reductions
Description
GLP-1 medications like semaglutide (Ozempic) and tirzepatide (Mounjaro) have traditionally been used to treat diabetes. They work by mimicking a natural hormone called GLP-1, which helps regulate blood sugar levels and appetite.
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Semaglutide and tirzepatide are both injectable medications used in medical weight managementbut they act on different metabolic pathways, which is why patient selection matters. Semaglutide (GLP-1 receptor agonist): Primarily targets appetite
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