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In the phase 3 ACHIEVE-1 trial, published in June 2025, the oral small-molecule GLP-1 receptor agonist orforglipron significantly reduced the glycated hemoglobin level over a period of 40 weeks in adults with

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Since January 2026, there have been six cases of acute liver toxicity associated with unapproved peptide products labelled Retatrutide in Australia. These toxic effects may be linked to a contaminant in the

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